Population Epigenetics Methods and Protocols
This detailed volume focuses on population epigenetics, which is of increasing interest to policy makers searching for explanations for complex epidemiological observations and conceptual models on which to base interventions. With a concentration on DNA
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Paul Haggarty Kristina Harrison Editors
Population Epigenetics Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Population Epigenetics Methods and Protocols
Edited by
Paul Haggarty Rowett Institute of Nutrition and Health University of Aberdeen Aberdeen, Scotland, UK
Kristina Harrison Rowett Institute of Nutrition and Health University of Aberdeen Aberdeen, Scotland, UK
Editors Paul Haggarty Rowett Institute of Nutrition and Health University of Aberdeen Aberdeen, Scotland, UK
Kristina Harrison Rowett Institute of Nutrition and Health University of Aberdeen Aberdeen, Scotland, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6901-2 ISBN 978-1-4939-6903-6 (eBook) DOI 10.1007/978-1-4939-6903-6 Library of Congress Control Number: 2017933297 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Population epigenetics is an emerging field that seeks to exploit the latest insights in epigenetics to improve our understanding of the factors that influence health and longevity. Epigenetics is at the heart of a series of feedback loops that allow crosstalk between the genome and its environment. Epigenetic status is influenced by a range of environmental exposures including diet and nutrition, lifestyle, social status, infertility and its treatment, and even the emotional environment. Early life has been highlighted as a period of heightened sensitivity when the environment can have long-lasting epigenetic effects. Epigenetic status is also influenced by genotype at the l
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