Fetal Stem Cells in Regenerative Medicine Principles and Translation

This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical c

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Dario O. Fauza Mahmud Bani Editors

Fetal Stem Cells in Regenerative Medicine Principles and Translational Strategies Foreword by Dr. Joseph Vacanti

Stem Cell Biology and Regenerative Medicine

Series Editor Kursad Turksen, Ph.D. [email protected]

More information about this series at http://www.springer.com/series/7896

Dario O. Fauza • Mahmud Bani Editors

Fetal Stem Cells in Regenerative Medicine Principles and Translational Strategies

Editors Dario O. Fauza Department of Surgery Boston Children’s Hospital and Harvard Medical School Boston, MA, USA

Mahmud Bani Department of Cellular and Molecular Medicine University of Ottawa, Faculty of Medicine Ottawa, ON, Canada

ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-1-4939-3481-2 ISBN 978-1-4939-3483-6 (eBook) DOI 10.1007/978-1-4939-3483-6 Library of Congress Control Number: 2016934211 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York

To the patients and their families, who may benefit from the developments discussed in this book To our mentors and colleagues, who share our quest for such developments To our families, who enrich our lives through love, care, and understanding amid our quest Dario O. Fauza and Mahmud Bani

Foreword

This book brings together two important fields of science and engineering with roots in the latter part of the twentieth century and propels them into the twenty-first century. Fetal biology and fetal therapy are interwoven into the disciplines of regenerative medicine and tissue engineering. The marriage is logical from many standpoints. Developmental biology has undergone explosive growth in new knowledge and understanding. The gene programs and signaling pathways in many ways overlap with the signaling of successful regeneration of tissues. M