Formation of Titania Submicron-Scale Rod Arrays on Titanium Substrate and In Vitro Biocompatibility
- PDF / 135,786 Bytes
- 6 Pages / 612 x 792 pts (letter) Page_size
- 32 Downloads / 227 Views
AA6.9.1
Formation of Titania Submicron-Scale Rod Arrays on Titanium Substrate and In Vitro Biocompatibility Satoshi Hayakawa1, Yongxing Liu1, Kazuya Okamoto1, Kanji Tsuru1,2 and Akiyoshi Osaka1,2 1
Biomaterials Laboratory, Okayama University, Tsushima, Okayama, 700-8530, Japan
2
Research Center for Biomedical Engineering, Okayama University, Tsushima, Okayama,
700-8530, Japan ABSTRACT Titania submicron-scale rod arrays were fabricated on metallic titanium (α-Ti) surfaces by coating a layer of sodium tetraborate on titanium substrates and subsequent thermal treatment. Thin-film X-ray diffraction analysis indicated that the sodium tetraborate gave rutile (TiO2: PDF# 21-1276) submicron-scale rod arrays. The rods in the arrays are parallel to each other in the grain of metallic titanium surface. The titania submicron-scale rod arrays deposited apatite within 7 days after being soaked in a simulated body fluid, indicating that the rod arrays exhibit in vitro bioactivity. INTRODUCTION Commercially available pure titanium (c.p. Ti) and its alloys are widely used for dental and orthopedic implants because of their high fracture toughness and good biocompatibility, although they cannot directly bond to bone. Many physical and chemical methods for surface modification of titanium implants have been already developed or proposed to provide them with the ability of direct bonding to bone tissues. Note that essential for such tissue-implant bonding is the in vivo apatite-forming ability of implant materials [1-4]. Chemical treatments of titanium substrates proposed so far [1-11] primarily aimed at controlling the formation of titania [2-10] or titanates [1,11] on the titanium substrate surfaces that induced apatite formation when those substrates were soaked in a simulated body fluid (SBF of the Kokubo’s recipe[12]). SBF was similar in inorganic ion composition to human blood plasma. In this study, we prepared titania submicron-scale rods array on metallic titanium (α-Ti) surfaces by coating a layer of sodium tetraborate on titanium substrates and subsequent thermal treatment. Thin-film X-ray diffraction analysis indicated that the sodium tetraborate gave rutile (TiO2: PDF# 21-1276) submicron-scale rod arrays. The in vitro biocompatibility of the titania
AA6.9.2
submicron-scale rod arrays was examined by the immersion experiment in a simulated body fluid in terms of the apatite-forming ability. EXPERIMENTAL DETAILS Reagent grade sodium carbonates and boron oxides (Nacalai Tesque Inc., Kyoto, Japan) were used to prepare the batches of Na2O·2B2O3 composition. They were melted in a platinum crucible with a cover and subsequently placed in an electric furnace at 1200°C for 1 h. The melts were then poured on a sheet of steel plate. The quenched glasses were grounded into powders that were less than 45 µm in diameter by a planetary micro-mill pulverizer, pulverisette-7 (Fritsch, Germany) at speed of 600 rpm for 10 min. A sheet of commercial pure titanium (Nilaco, Osaka, Japan) was cut to give pieces of Ti substrate with of 10x
Data Loading...
