Hydroxychloroquine
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Bull’s-eye maculopathy: 5 case reports In an observational, retrospective study involving 31 patients, five women aged 48–58 years were described, who developed bull’s-eye maculopathy following treatment with hydroxychloroquine for systemic lupus erythematosus or Sjogren syndrome [routes, times to reactions onsets and outcomes not stated]. The women, who had systemic lupus erythematosus (4 patients) or Sjogren syndrome (1 patient), had been undergoing treatment with hydroxychloroquine 4.4–8.9 mg/kg daily since 5–20 years; the total hydroxychloroquine dose ranged from 730g–2798g. Amongst the 5 women, 3 women had discontinued hydroxychloroquine treatment 0.5–30 months before presentation. Eventually, all the women presented for ophthalmological evaluation. Upon presentation, the women underwent visual field tests, multifocal electroretinography, spectral-domain optical coherence tomography, short-wavelength fundus autofluorescence and near-infrared fundus autofluorescence, following which, all women were diagnosed with hydroxychloroquine associated toxic bull’s-eye maculopathy. Greenstein VC, et al. Quantitative fundus autofluorescence in HCQ retinopathy. Investigative Ophthalmology and Visual Science 61: No. 11, 25 Sep 2020. Available from: 803519486 URL: http://doi.org/10.1167/IOVS.61.11.41
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Reactions 5 Dec 2020 No. 1833
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