Hydroxychloroquine
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DRESS syndrome: case report A 69-year-old woman developed DRESS syndrome during treatment with hydroxychloroquine for lichen planopilaris of the trunk. The woman was hospitalised for maculopapular itchy eruption with erythema multiforme-like aspect on the trunk and wholebody surface with massive exfoliation and multiple lymphadenopathies. The overall skin rash extent was more than 50% body surface area. The temperature was 38.7°C. Laboratory investigations showed leucocytosis, absolute eosinophilia, abnormal renal function and increased C-reactive protein. Polymerase chain reaction for human herpesvirus 7 was found to be positive in both serum and whole blood. Serological investigations were negative. Bilateral inguinal lymph nodes enlargement was noted upon fullbody CT scan. Histopathological examination showed interface dermatitis and apoptotic keratinocytes. Her history showed that she had been receiving treatment with hydroxychloroquine 400 mg/day [route not stated] for lichen planopilaris of the trunk. It was reported that, she developed skin lesions 20 days after the initiation of hydroxychloroquine. Additionally, she was receiving treatment with levothyroxine sodium [levothyroxine], unspecified proton pump inhibitors and unspecified angiotensin-converting enzyme inhibitors concomitantly. RegiSCAR score was 7 indicating definite relationship between DRESS syndrome and hydroxychloroquine . The woman’s treatment with hydroxychloroquine was discontinued, and she was treated with methylprednisolone. Eventually, her skin lesions and laboratory abnormalities were resolved in 1 and 2 months, respectively. Grandolfo M, et al. Drug reaction with eosinophilia and systemic symptoms syndrome to hydroxychloroquine, an old drug in the spotlight in the COVID-19 era. Dermatologic 803507618 Therapy 33: No. 4, Jul-Aug 2020. Available from: URL: http://doi.org/10.1111/dth.13499
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Reactions 17 Oct 2020 No. 1826
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