Hydroxychloroquine
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Atypical hydroxychloroquine maculopathy: case report A 49-year-old woman developed atypical hydroxychloroquine maculopathy during treatment with hydroxychloroquine for systemic lupus. The woman, who had systemic lupus, had been receiving hydroxychloroquine treatment 400 mg/day for 26 years [route not stated]. Previously, she was monitored at another centre using a 10-2 visual field. At that time, visual field and macular optical coherence tomography (OCT) was normal. Afterwards, she presented with a picture of toxicity to hydroxychloroquine in its pericentral form. Fundus autofluorescence showed irregular double hyperautofluorescent border. The internal border borders the macular zone, the external border protruded on the middle periphery. Both right eye and left eye showed static visual field of central 30° showing bilateral pericentral annular scotoma which had not been detected previously. OCT of wide horizontal and vertical macular sections (right eye and left eye) showed retinal thinning associated with a disappearance of the perimacular ellipsoid layer opposite the areas bordered by the hyperautofluorescent borders. The foveal retinal architecture was preserved. The findings were consistent with atypical hydroxychloroquine maculopathy [duration of treatment to reaction onset and outcome not stated]. Messiant V, et al. Atypical hydroxychloroquine maculopathy in an Asian woman with lupus. Journal Francais d’Ophtalmologie 42: 1134-1136, No. 10, Dec 2019. Available 803497992 from: URL: http://doi.org/10.1016/j.jfo.2019.05.032 [French; summarised from a translation]
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Reactions 29 Aug 2020 No. 1819
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