Hydroxychloroquine
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Hydroxychloroquine Lichenoid eruption: case report A 43-year-old woman developed a lichenoid eruption while receiving hydroxychloroquine for cutaneous lupus erythematosus. The woman was prescribed hydroxychloroquine 200mg three times daily with the frequency of administration later reduced to twice daily. Approximately 1 year after starting the agent, she developed lesions on her hands, and also intravaginal and intra-oral lesions. A physical examination performed 3 years later for refractory lesions revealed lichenoid papules and linear plaques on the margins of her lips, and lacy white streaks on her buccal mucosa, along with erythematous plaques. Erosive plaques affecting the dorsal aspects of her fingers and the majority of her nail folds were also present. Skin biopsy findings were consistent with a lichenoid eruption overlapping her erythematous lesions. Hydroxychloroquine was discontinued and azathioprine was started. At follow-up 1 year later her lupus erythematosus lesions remained but her lichenoid lesions had resolved. Author comment: In cases of lichenoid eruptions induced by antimalarial medications in patients with inflammatory disorders such as cutaneous lupus erythematosus or dermatomyositis, "it can be difficult to distinguish the primary disorder from the medication induced exacerbation or concomitant cutaneous eruption". Weinel S, et al. Hydroxychloroquine-induced lichenoid eruption in a patient with cutaneous lupus erythematosus. Journal of the American Academy of Dermatology 801100066 58 (Suppl. 2): 36, No. 2, Feb 2008 [abstract] - USA
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Reactions 2 Feb 2008 No. 1187
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