IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been c
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Vale´rie Quesniaux • Bernhard Ryffel • Franco Di Padova Editors
IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity
Editors Vale´rie Quesniaux Bernhard Ryffel UMR7355 INEM Experimental and Molecular Immunology and Neurogenetics CNRS et Universite´ d’Orleans Orleans - Cedex 2 France
Franco Di Padova Novartis Institute for Biomedical Research (NIBR) Novartis Pharma AG Basel Switzerland
ISBN 978-3-0348-0521-6 ISBN 978-3-0348-0522-3 (eBook) DOI 10.1007/978-3-0348-0522-3 Springer Basel Heidelberg New York Dordrecht London Library of Congress Control Number: 2012953357 1st edition: # Th 17 Cells: Role in Inflammation and Autoimmune Disease. Birkha¨user Verlag AG 2009 2nd edition: # Springer Basel 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer Basel is part of Springer Science þ Business Media (www.springer.com)
Preface
The IL-17 cytokines represent a novel family of cytokines, which extends the Th1-Th2 paradigm and defines a new effector T cell, the Th17 cell. Th17 cells may co-express at least IL-17A and IL-17F and IL-22. IL-17A and IL-17F can be produced by CD4þ T cells (Th17 cells), CD8þ T cells (Tc17), gd T cells, iNKT, NK cells, lymphoid tissue inducers cells, innate lymphoid cells, mast cells, neutrophils and Paneth cells. IL
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