Low-cost synthesis of carbon nanodots from millets for bioimaging
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MRS Advances © 2019 Materials Research Society DOI: 10.1557/adv.2019.12
Low-cost synthesis of carbon nanodots from millets for bioimaging Ngo Khoa Quang1 and Che Thi Cam Ha2 1
Faculty of Physics, University of Sciences, Hue University, 77 Nguyen Hue, Hue City, Vietnam
2
Faculty of Biology, University of Sciences, Hue University, 77 Nguyen Hue, Hue City, Vietnam.
ABSTRACT
We presented a green and simple method to synthesize carbon nanodots (C-dots) from millets using hydrothermal synthesis route for the first time. The obtained C-dots have average diameter ranging from 6 to 10 nm. Optical measurements showed the insight into the formation of functional groups on the particle surfaces, resulting in their good water solubility and bioconjugation. After treatment with C-dots, small subpopulation of the human cervical tumor cells became bright and exhibited multicolor fluorescence under different excitation wavelength. The achievement demonstrated potential applications of fluorescent C-dots in the field of biomedical application.
INTRODUCTION: Inorganic semiconductor quantum dots have many intriguing features and are currently intensively researched [1]. In term of biomedical application, quantum dots create expected effects, such as bright fluorescence, high biocompatibility, excellent photostability and so forth [1-3]. Among new generation of quantum dots, carbon quantum dots (C-dots) display many interesting features and are considered as a fascinating substitute for traditional semiconductor quantum dots [4-7]. In this context, C-dots possess not only advantageous characteristics of semiconductor quantum dots but also low cytotoxicity [4, 8]. Up to now, there is a large number of approaches to fabricate C-dots from chemical reagents as well as natural biomass [9-12]. Consequently, hydrothermal
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synthesis route is considered as favourable method because of its inexpensive apparatus and low energy consumption [12]. Furthermore, in the effort to improve the eco-friendly approaches, natural biomass provides an ideal source for scientists to prepare C-dots. Several results using hydrothermal strategy for the preparation of C-dots from natural bioresources have been reported [9, 13-15]. Concerning to millets, the carbohydrate in total main nutrient is even up to 70% and it is could serve as a great carbonaceous precursor for C-dots synthesis [16, 17]. In our study, we report a low cost and green synthesis of C-dots from millets by hydrothermal treatment for the first time. Optical measurements was performed to provide information on excitation wavelength dependence of C-dots as well as the functional groups on surface of carbon core. In particular, we attempted to examine bioconjugation by incubating human cervical cancer cells with the obtained C-dots. It would provide us
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