Measles Virus
Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figu
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Editors A. Capron, Lille . R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama· H. Koprowski, Philadelphia· I. McConnell, Edinburgh· F. Melchers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La Jolla/California· H. Wagner, Munich I. Wilson, La Jolla/California
Measles Virus
Edited by Volker ter Meulen and Martin A. Billeter With 23 Figures and 3 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
VOLKER TER MEULEN
Institut fur Virologie und Immunbiologie der Universitat Wurzburg Versbacher Strasse 7 97078 Wurzburg, Germany MARTIN
A.
BILLETER
Institut fur Molekularbiologie I Universitat Zurich H6nggerberg 8093 Zurich, Switzerland
Cover Illustration: According to a drawing by Toni Cathomen and Roberto Cattaneo.
Cover design: Kunkel und Lapka, IIvesheim ISBN-13: 978-3-642-78623-5 DOl 10.1007/978-3-642-78621-1
e-ISBN-13 978-3-642-78621-1
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© Springer-Verlag Berlin Heidelberg 1995 Softcover reprint of the hardcover 1st edition 1995 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting other relevant literature. Production: PRODUserv Springer Produktions-Gesellschaft, Berlin SPIN: 10096419
27/3020-5432 1 0 - Printed on acid-free paper.
Preface
Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figures were roughly three times higher. Attenuated measles virus (MV) strains, all quite closely related to the original Edmonston isolate, have a very good record as a safe and highly efficacious vaccine and have brought down the measles toll in industrialized countries to almost negligible levels. However, recent outbreaks in the USA and Europe have again brought the measles problem to public attention. Sadly enough, these outbreaks were more instrumental in inducing activities to drastically r
