Microfluidic devices with gold thin film channels for chemical and biomedical applications: a review
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Microfluidic devices with gold thin film channels for chemical and biomedical applications: a review Mahtab Ghasemi Toudeshkchoui 1 & Navid Rabiee 2 & Mohammad Rabiee 3 & Mojtaba Bagherzadeh 2 & Mohammadreza Tahriri 4 & Lobat Tayebi 4 & Michael R. Hamblin 5,6,7
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Microfluidic systems (MFS) provide a range of advantages in biomedical applications, including improved controllability of material characteristics and lower consumption of reagents, energy, time and money. Fabrication of MFS employs various materials, such as glass, silicon, ceramics, paper, and metals such as gold, copper, aluminum, chromium and titanium. In this review, gold thin film microfluidic channels (GTFMFC) are discussed with reference to fabrication methods and their diverse use in chemical and biomedical applications. The advantages of gold thin films (GTF) include flexibility, ease of manufacture, adhesion to polymer surfaces, chemical stability, good electrical conductivity, surface plasmon resonance effects, ability to be chemically functionalized, etc. Various electroactuators and electroanalytical devices can incorporate GTF. GTF-based MFS have been used in environmental monitoring, assays of biomarkers, immunoassays, cell culture studies and pathogen identification. Keywords Microfluidic systems . Gold thin film channels . Biomedical applications . Surface plasmonic resonance . Electrochemical sensors
1 Introduction In recent decades, the microelectronics industry has introduced the use of microfluidic systems. These systems, named “lab-on-a-chip” (LOC), were developed as a natural consequence of advances in integrated electronic circuits (IC) and micro- and nano-electromechanical systems (MEMS and NEMS). This is now a fast moving field involving ever more
* Mohammadreza Tahriri [email protected]
miniaturization of laboratory assays and equipment, especially for laboratory simulation of organs in order to construct a single “organ-on-a-chip” model which can allow more effective, complex and complete analysis of tissues and organs (Francesko and Cardoso 2019; Bruus 2008; Temiz et al. 2015; Theor 2008; Nasseri et al. 2018; Farjadian et al. 2018). Digital microfluidics (DMF) is an integration of electrochemical detection systems with microfluidic devices
1
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
2
Department of Chemistry, Sharif University of Technology, Tehran, Iran
3
Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
Navid Rabiee [email protected]
4
Department of Developmental Sciences, Marquette University, Milwaukee, WI 53233, USA
Mohammad Rabiee [email protected]
5
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, USA
Mojtaba Bagherzadeh [email protected]
6
Department of Dermatology, Harvard Medical School, Boston, USA
7
Harvard-MIT Division of Health Sciences and Technology, Cambridge, U
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