Molecular Imaging II

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the int

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Volume 185/II

Editor-in-Chief F. Hofmann, München Editorial Board J. Beavo, Seattle, WA D. Ganten, Berlin M. Michel, Amsterdam C. Page, London W. Rosenthal, Berlin

Wolfhard Semmler



Markus Schwaiger

Editors

Molecular Imaging II Contributors F. Blankenberg, R. Blasberg, A. Bogdanov, R.G. Boy, C. Bremer, R. Deckers, S.L. Deutscher, I. Dijkgraaf, M. Eisenhut, S.S. Gambhir, A. Haase, R. Haubner, A.H. Jacobs, P.M. Jakob, U. Haberkorn, A. Hagooly, K.-H. Hiller, R. Huang, F. Kiessling, L.W. Kracht, P. Mayer-Kukuck, W. Mier, J.-J. Min, C.T.W. Moonen, J. Newton, M. Querol, C. Rome, R. Rossin, M.A. Rueger, I. Serganova, H.W. Strauss, J. Tait, A.V. Thomas, J.-L. Vanderheyden, C. Waller, M.J. Welch, H.J. Wester, A. Winkeler

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Prof. Dr. rer. nat. Dr. med. Wolfhard Semmler Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020) Forschungsschwerpunkt Innovative Krebsdiagnostik und -therapie (E) Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 69120 Heidelberg Germany [email protected]

ISBN: 978-3-540-77449-5

Prof. Dr. med. Markus Schwaiger Nuklearmedizinische Klinik und Poliklinik Klinikum rechts des Isar des Technischen Universität München Ismaninger Str. 22 81675 München Germany [email protected]

e-ISBN: 978-3-540-77496-9

Handbook of Experimental Pharmacology ISSN 0171-2004 Library of Congress Control Number: 2007943479 c Springer-Verlag Berlin Heidelberg 2008 

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover Design: WMXDesign GmbH, Heidelberg Printed on acid-free paper 9 8 7 6 5 4 3 2 1 springer.com

Foreword

Bayer Schering Pharma welcomes Springer Verlag’s endeavor to open its wellknown Handbook of Pharmacology to the exciting field of molecular imaging and we are pleased to contribute to the printing costs of this volume. In principle, noninvasive diagnostic imaging can be divided into morphological/anatomical imaging on the one hand, with CT/MRI the most important imaging technologies, and molecular imaging on the other. In CT/MRI procedures, cont