Mouse Retinal Phenotyping Methods and Protocols
The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of ou
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Naoyuki Tanimoto Editor
Mouse Retinal Phenotyping Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Mouse Retinal Phenotyping Methods and Protocols
Edited by
Naoyuki Tanimoto Department of Ophthalmology, University Hospital Schleswig-Holstein, Kiel, Germany
Editor Naoyuki Tanimoto Department of Ophthalmology University Hospital Schleswig-Holstein Kiel, Germany
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7719-2 ISBN 978-1-4939-7720-8 (eBook) https://doi.org/10.1007/978-1-4939-7720-8 Library of Congress Control Number: 2018934980 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Over the past decades, progress in molecular biology has led to the generation of a variety of genetic mouse models with retinal phenotypes that have contributed to major advances in our understanding of retinal pathophysiology. Furthermore, mouse models carrying genetic defects, comparable to those of human hereditary retinal disorders, have been applied to preclinical research for the evaluation of therapeutic intervention, some of which are now being translated into clinical trials. A reliable assessment of such research depends on an accurate and precise characterization of the retina. The aim of this volume Mouse Retinal Phenotyping: Methods and Protocols is to provide a wide range of techniques and aspects of mouse retinal phe
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