Peptide Antibodies Methods and Protocols
This extensive volume covers basic and advanced aspects of peptide antibody production, characterization, and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For
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Gunnar Houen Editor
Peptide Antibodies Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Peptide Antibodies Methods and Protocols
Edited by
Gunnar Houen Statens Serum Institut, Copenhagen, Denmark
Editor Gunnar Houen Statens Serum Institut Copenhagen, Denmark
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2998-6 ISBN 978-1-4939-2999-3 (eBook) DOI 10.1007/978-1-4939-2999-3 Library of Congress Control Number: 2015948252 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Cover Illustration: Image provided by Tim Vickers. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface The ability to design and produce peptide antibodies has had a large impact on molecular cell biology and immunology, including all the different techniques involved (immunoassays, immunoprecipitation, immunoblotting, immunohistochemistry, etc). This large impact is a result of several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells, and T cells. Moreover, although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest (phosphorylation, citrullination, etc.) and different forms of recombinant peptide antibodies are gaining interest (nanobodies, single c
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