Peptide Microarrays Methods and Protocols
This expert volume provides insights into the technological fundamentals together with a comprehensive overview of the potentialities of peptide microarray technology in basic research and clinical assays. Advancements made in recent years in peptide libr
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Marina Cretich Marcella Chiari Editors
Peptide Microarrays Methods and Protocols Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Peptide Microarrays Methods and Protocols Second Edition
Editors
Marina Cretich Consiglio Nazionale delle Ricerche, Milano, Italy
Marcella Chiari Consiglio Nazionale delle Ricerche, Milano, Italy
Editors Marina Cretich Consiglio Nazionale delle Ricerche Milano, Italy
Marcella Chiari Consiglio Nazionale delle Ricerche Milano, Italy
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3036-4 ISBN 978-1-4939-3037-1 (eBook) DOI 10.1007/978-1-4939-3037-1 Library of Congress Control Number: 2015950855 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Peptide microarrays, with their unlimited content flexibility, are formidable tools in many areas of biochemistry and medicine. For example, they enable the design of enzyme inhibitors and enhancers or advance structural and functional information on protein interactions. When employed in epitope mapping, they serve to identify antibody binding domains that can be implemented in vaccine and new therapeutics development. Peptide microarrays can also diagnose diseases. By the design of peptide arrays incorporating epitope collections, the huge amount of immunological information hidden in the plasma of an individual can be revealed, thus profiling his or her personalized immunoresponse to infection, vaccination, allergens, and autoimmunity and providing hints on new biomarkers. Peptides in a miniaturized and mult
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