Protective effect of rosmarinic acid against oxidative stress biomarkers in liver and kidney of strepotozotocin-induced
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ORIGINAL PAPER
Protective effect of rosmarinic acid against oxidative stress biomarkers in liver and kidney of strepotozotocin-induced diabetic rats Nadia Mushtaq & Roberta Schmatz & Mushtaq Ahmed & Luciane Belmonte Pereira & Pauline da Costa & Karine Paula Reichert & Diéssica Dalenogare & Luana Paula Pelinson & Juliano Marchi Vieira & Naiara Stefanello & Lizielle Souza de Oliveira & Nadia Mulinacci & Maria Bellumori & Vera Maria Morsch & Maria Rosa Schetinger
Received: 19 August 2014 / Accepted: 23 September 2015 # University of Navarra 2015
Abstract In the present study, we investigated the efficiency of rosmarinic acid (RA) in preventing the alteration of oxidative parameters in the liver and kidney of diabetic rats induced by streptozotocin (STZ). The animals were divided into six groups (n=8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol, and diabetic/RA 10 mg/kg. After 3 weeks of treatment, we found that TBARS levels in liver and kidney were significantly increased in the diabetic/saline group and the administration of RA
N. Mushtaq : R. Schmatz (*) : L. B. Pereira : P. da Costa : K. P. Reichert : D. Dalenogare : L. P. Pelinson : J. M. Vieira : N. Stefanello : L. S. de Oliveira : V. M. Morsch : M. R. Schetinger (*) Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitário, Camobi, 97105-900, Santa Maria, RS, Brazil e-mail: [email protected] e-mail: [email protected] M. Ahmed Department of Biotechnology, University of Science and Technology, Bannu, Khyber Pakhtunkhwa, Pakistan
: M. Bellumori
N. Mulinacci Department of NEUROFARBA, University of Florence, Via Ugo Schiff 6, Sesto F.no (Firenze) 50019, Italy R. Schmatz Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, IFRS-Câmpus Ibirubá, 98200-000 Ibirubá, Brazil
prevented this increase in the liver and kidney (P
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