2006 Annual Meeting Student Poster Abstracts
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2006 Annual Meeting Student Poster Abstracts The accepted Student Poster Abstracts for the 2006 DIA Annual Meeting are printed below. The posters will be on display in a dedicated area outside the Exhibit Hall. The Student
Antibacterial, Resistant Modifying, and Antioxidant Activity of Paullinia pinnata K. Annan, P. J. Houghton, P. J.Hylands, S. Gibbons' Kings College 'University of London In traditional medicine in Ghana, Paullinia pinnata (Sapindaceae) is used for the treatment of wounds and other microbial infections. The objective of the current study is to assess the antimicrobial and antioxidant properties of the plant which may underline its wound healing properties. The roots were exhaustively extracted with methanol using soxhlet apparatus. Bioassay-guided fractionation of the methanol extract using an antibacterial assay determined that the petroleum ether and chloroform fractions were active while acetone, methanol and water fractions were inactive. Column chromatography followed by preparative thin layer chromatography (TLC) led to the isolation of five compounds, K1, K2, K3, K9 and K11 from the active fractions which were assessed for their antibacterial activities against different strains of Staphylococcus aureus (XU212 (TetK),RN4220 (MsrA) and SA1199B (NorA)) possessing efflux mechanism of resistance. The antioxidant action of the crude extract and the isolated compounds was assessed by their ability to scavenge DPPH radical. All compounds had antibacterial effects with minimum inhibitory concentrations (MIC) ranging from 1-256yg/ml, the most active being K11 with MIC ranging from 1-4pg/ml. Incorporation of K11 in the bacterial growth medium at O.lpg/ml caused an 8-fold (norfloxacin), 256-fold ( tetracycline) and 712fold (erythromycin) potentiation of activities against SA1199B, XU212 and RN4220 respectively. The crude methanol extract had a strong radical scavenging activity (SC,, 3.8pg/ml) whilst the isolated compounds had weak activities. The findings above strongly support the folkloric use of the plant as a natural health product in wound healing.
Has International Access to New Medicines Improved i n the Post-ICH Period? lmogen Carr,' Mayu Hirako,' Neil McAuslane,' Sam Salek,' Stuart Walker2 'Cardiff University Kenter for Medicines Research International Background Global pharmaceutical research and development expenditure has increased by 75% over the last 10 years to US$56 billion per
Poster Session will take place on Monday, June 19,from 10AM to 6 PM in the Arch Street Bridge on the second floor of the Pennsylvania Convention Center.
year, while the number of New Active Substances (NASs) reaching the market for the first time is declining: As the number of NASs declines companies are looking to maximise the return on new medicines, particularly in relation to the speed at which NASs can be rolled out globally in a changing regulatory and commercial environment. Objectives To evaluate and compare submission patterns and approval times across six leading regulatory agencies for NASs
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