A hand-held beta imaging probe for FDG
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ORIGINAL ARTICLE
A hand-held beta imaging probe for FDG Bipin Singh • Brendan C. Stack Jr. • Samta Thacker Valeriy Gaysinskiy • Twyla Bartel • Val Lowe • Steven Cool • Gerald Entine • Vivek Nagarkar
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Received: 11 April 2012 / Accepted: 25 November 2012 / Published online: 11 December 2012 Ó The Japanese Society of Nuclear Medicine 2012
Abstract Objectives Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta ProbeTM (IBPTM) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as 18FDG, 131 I and 32P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments. Methods We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of 18FDGavid primary tumors and metastases in an animal model. Results We have demonstrated a device which can generate beta images from 18FDG avid lesions in an animal model. Conclusions It is feasible to image beta irradiation in animal models of cancer given 18FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction
B. Singh S. Thacker V. Gaysinskiy S. Cool G. Entine V. Nagarkar Radiation Monitoring Devices, Inc., Watertown, MA 02472, USA B. C. Stack Jr. (&) T. Bartel University of Arkansas for Medical Sciences, 4301 W. Markham St, #543, Little Rock, AR 72205, USA e-mail: [email protected] V. Lowe Mayo Clinic, Rochester, MN 55906, USA
of malignancy may aid the surgeon in localization and excision of lesions of interest. Keywords
18
FDG PET
131
I Imaging Beta probe
Introduction Advances in radiopharmaceuticals, radiation detectors, and clinical understanding have escalated the use of intraoperative radiation-detecting probes in surgery, providing benefits that include increased specificity in tissue resected or obtained for biopsy, minimal access incisions, and the potential for reduction of inpatient hospital utilization and hastened patient recovery. The merits of such probes and radiopharmaceuticals in diagnostic medical imaging have been clinically proven [1–5]. At present, most probes on the market are non-imaging gamma probes that are used during surgery, typically for sentinel lymph node dissection and parathyroid adenoma resection. The effectiveness of these probes is limited, however, since they suffer from a lack of ancillary information of the surveyed area, such as the clear delineation of margins of radioactive tissue. Also, the highly penetrating gamma radiation present locally or even in remote parts of the body increases the background radiation level and further limits their discriminating value. To address the chal
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