Aciclovir
- PDF / 141,611 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 40 Downloads / 127 Views
1
S
Acute renal failure: case report A 23-year-old man developed acute renal failure following treatment with aciclovir for suspected meningitis/ encephalitis. The man, who was morbidly obese, received IV aciclovir 10 mg/kg every 8 hours for suspected meningitis/ encephalitis requiring hospitalisation. His renal function declined significantly within 48 hours of initiating aciclovir. Blood tests performed on day 2 revealed the following values: creatinine 172 µmol/L, urea 5.2 mmol/L. haemoglobin 14.7 g/dL, CRP 3 mg/L, platelets 231 × 109/L and WBC count 10.8 × 109/L. Repeat tests on day 4 showed the following values: creatinine 692 µmol/L, urea 13.5 mmol/L, haemoglobin 12.3 g/dL, CRP 74 mg/L, platelets 209 × 109/L and WBC count 10 × 109/L. His differential diagnosis included acute renal failure secondary to aciclovir. Aciclovir was withdrawn; the man received a total of four doses of aciclovir 1.1g (total 4.4g). His renal function subsequently normalised. Author comment: "Acyclovir-induced acute renal failure has been well documented and is due to intra-tubular crystal precipitation. . . In this case, nephrotoxicity secondary to acyclovir therapy may be due to prescribing drugs according to the TBW [total body weight] resulting in very large doses of the drug being given." Seedat A, et al. Acyclovir-induced acute renal failure and the importance of an expanding waist line. BMJ Case Reports : 1-3, 12 Jul 2012. Available from: URL: 803077863 http://dx.doi.org/10.1136/bcr-2012-006264 - United Kingdom
0114-9954/10/1421-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 29 Sep 2012 No. 1421
Data Loading...
