Aciclovir
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Nephrotoxicity and neurotoxicity: case report An 82-year-old woman developed nephrotoxicity and neurotoxicity during treatment with aciclovir for herpes simplex and varicella zoster encephalitis. The woman presented with vesicular rash and delirium and subsequently diagnosed with herpes simplex and varicella zoster virus infection. She started receiving treatment with IV aciclovir [acyclovir] 800mg three times a day. This resulted in improvement in her mental status, but after 48 hours, laboratory tests showed an abrupt 5 fold increase in serum creatinine levels. Thus, nephrotoxicity secondary to aciclovir was suspected. The woman’s aciclovir was stopped. The next day, she exhibited speech disturbances and psychomotor agitation consistent with neurotoxicity secondary to aciclovir therapy. Thus, further treatment was started with valaciclovir (prodrug of aciclovir). Following initiation of valaciclovir, serum creatinine and urinary output normalised and her mental status also returned to normal. After a 10 days course of valaciclovir, she was discharged home. Maldonado Slootjes S, et al. Valacyclovir in the treatment of herpes simplex and varicella zoster encephalitides. European Journal of Neurology 27 (Suppl. 1): 1181 abstr. 803498563 EPO3272, May 2020. Available from: URL: https://onlinelibrary.wiley.com/toc/14681331/2020/27/S1 [abstract]
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 29 Aug 2020 No. 1819
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