Adhesion of Cells, Viruses and Nanoparticles
"Adhesion of Cells, Viruses and Nanoparticles" describes the adhesion of cells, viruses and nanoparticles starting from the basic principles of adhesion science, familiar to postgraduates, and leading on to recent research results. The underlying theory i
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Kevin Kendall Michaela Kendall Florian Rehfeldt ●
Adhesion of Cells, Viruses and Nanoparticles
Professor Kevin Kendall Chemical Engineering University of Birmingham Edgbaston B15 2TT UK [email protected] Dr Michaela Kendall Peninsula College of Medicine and Dentistry The Knowledge Spa Truro Cornwall TR1 3HD UK [email protected]
Dr Florian Rehfeldt Georg-August-Universität Göttingen 3rd Institute of Physics - Biophysics Friedrich-Hund-Platz 1 37077 Göttingen Germany [email protected]
ISBN 978-90-481-2584-5 e-ISBN 978-90-481-2585-2 DOI 10.1007/978-90-481-2585-2 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010937429 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
It is now 100 years since adhesion of cells was shown to be vital for their growth and reproduction. Ross Granville Harrison, Fig. 1, invented the technique for culturing cells, a technique which is now of massive importance for studying genetics, cancer, tissue engineering and disease processes. Harrison was a 37 year old lecturer at Johns Hopkins in the USA, observing the growth of nerve fibres in embryos, when he found that he could insert solid blood clot material into the animal and the cells would continue to propagate along the
Fig. 1 Ross Granville Harrison 1870–19591 (with permission of Royal Society) v
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Preface
foreign material. Subsequently in 1907 he found that the nerve cells would also grow on the blood clot in a dish outside the embryo. In his 1914 paper,2 he then showed that the shape of the cells depended on the solid substrate by testing the cells on clotted plasma, spider web fibres and glass cover slips. This was the first indication that adhesion was essential for shape and differentiation of cells. It is interesting that 100 years have also elapsed since the discovery that viruses can cause animal disease. Ellerman and Bang3 in 1908 showed that leukaemia could be transmitted to chickens by injecting cell free material. A few years later, Rous4 in 1910 and 1911 showed that solid tumours could be transferred from chicken to chicken to spread the disease and also isolated the infective agent in a cell free filtrate. It later became clear that the virus particles, which at that time could not be imaged by microscopy, were adhering to the cells to cause infection. Rous received the Nobel Prize for this work in 1966, more than 50 years after his observations. There was no model at that time to describe the mechanism by which the virus particle attached to and entered the ce
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