Administration of alpha-lipoic acid could maintain bone mass and bone strength in senile female rats with alcohol consum
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Gerontologie+Geriatrie Original Contributions Z Gerontol Geriat https://doi.org/10.1007/s00391-019-01630-3 Received: 5 February 2019 Accepted: 17 September 2019 © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019
Introduction There is growing cause for concern about global epidemic osteoporosis, where estrogen deficiency results in bone resorption outpacing bone formation, a condition associated with a decrease in bone quality and quantity [1, 2]. The major complication of osteoporosis is an increase in fragility fractures leading to morbidity, mortality, and decreased quality of life. A recent study reported an annual incidence rate for hip fractures as 163 and 121 per 100,000 inhabitants per year in women and men over 55 years old, respectively [3]. In addition to unmodifiable risk factors such as age and sex, several nutritional and lifestyle factors including low calcium (Ca) intake and low physical activity are recognized as important risk factors for the development of osteoporosis [4]. Excessive alcohol intake is well-known to derange bone metabolism and cause secondary osteoporosis [5]. Alcohol abuse is associated with increased incidence of fracture risk in spine and hip and complications in fracture healing, and there are changes in bone structure detected by histomorphometry and there is a decrease in bone mineral content [6]. Alcohol consumption is a potent inhibitor of bone growth in rats and can result in a deJunfeng Zhan and Ya Jiang contributed equally to this work and share the first author.
Junfeng Zhan1 · Ya Jiang2 · Nan Zhu1 · Wang Fang1 · Gang Wang3 1
Department of orthopaedics Surgery, The Second Hospital of Anhui Medical University, Hefei, China Department of Orthopaedics, Hefei Third People’s Hospital, Hefei, China 3 Department of orthopaedics Surgery, Nanfang Hospital Southern Medical University, Guangzhou, China 2
Administration of alpha-lipoic acid could maintain bone mass and bone strength in senile female rats with alcohol consumption crease in peak bone mass [7], which may predispose the skeleton to osteoporosis during aging. One factor that plays a central role in alcohol-induced osteoporosis is the excessive generation of free radicals, which in turn causes oxidative stress and eventually leads to formation of reactive oxygen species and increase in cytokine production [8]. Alphalipoic acid (ALA) is a naturally occurring antioxidant through several mechanisms, including scavenging of free radicals, chelation of metal ions, and regeneration of endogenous and exogenous antioxidants, which has been implicated in the prevention or alleviation of neurodegeneration, ischemia reperfusion injury, Acquired Immune Deficiency Syndrome (AIDS), and hepatic diseases [9]. Recently, ALA has received much attention because of its effects on osteoblasts and osteoclasts due to its strong anti-oxidative activity. Furthermore, research has demonstrated a promising mix of protective and curative actions of ALA on the bone of ovariectomized (OVX) rats [10]. Those studies addressed the effect of
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