Advances in metabolomics of thyroid cancer diagnosis and metabolic regulation
- PDF / 1,140,485 Bytes
- 14 Pages / 595.276 x 790.866 pts Page_size
- 47 Downloads / 207 Views
REVIEW
Advances in metabolomics of thyroid cancer diagnosis and metabolic regulation Raziyeh Abooshahab1 Morteza Gholami1,2 Maryam Sanoie1 Fereidoun Azizi3 Mehdi Hedayati1 ●
●
●
●
1234567890();,:
1234567890();,:
Received: 16 January 2019 / Accepted: 13 March 2019 © Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Thyroid cancers (TCs) are the most frequent endocrine malignancy with an unpredictable fast-growing incidence, especially in females all over the world. Fine-needle aspiration biopsy (FNAB) analysis is an accurate diagnostic method for detecting thyroid nodules and classification of TC. Though simplicity, safety, and accuracy of FNAB, 15–30% of cases are indeterminate, and it is not possible to determine the exact cytology of the specimen. This demands the need for innovative methods capable to find crucial biomarkers with adequate sensitivity for diagnosis and prediction in TC researches. Cancer-based metabolomics is a vast emerging field focused on the detection of a large set of metabolites extracted from biofluids or tissues. Using analytical chemistry procedures allows for the potential recognition of cancer-based metabolites for the purposes of advancing the era of personalized medicine. Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) coupled with separation techniques e.g., gas chromatography (GC) and liquid chromatography (LC) are the main approaches for metabolic studies in cancers. The immense metabolite profiling has provided a chance to discover novel biomarkers for early detection of thyroid cancer and reduce unnecessary aggressive surgery. In this review, we recapitulate the recent advances and developed methods of diverse metabolomics tools and metabolic phenotypes of thyroid cancer, following a brief discussion of recent challenges in the thyroid cancer diagnosis. Keywords Thyroid cancer diagnosis Metabolomics Early detection NMR GC/MS LC/MS ●
●
Introduction Thyroid cancer (TC) is the most common endocrine disorder. The worldwide incidence of this type of cancer has been dramatically growing in recent years, with the average age of the individuals at diagnosis being 30–39 years [1]. It has become the fifth most common cancer in females with the global highest incidence rate (three times higher than men) [2–4]. The greater prevalence of thyroid cancer in
* Mehdi Hedayati [email protected] 1
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2
Department of Chemistry, Faculty of Science, Golestan University, Gorgan, Iran
3
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
●
●
●
females suggests that hormonal factors may be involved in its development [5]. Noteworthy, thyroid cancers often appear as thyroid nodules, therefore, the diagnosis and follow-up of this type of cancer is associated with thyroid nodules. This type of cancer may occurs du
Data Loading...
