Atorvastatin
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Rhabdomyolysis: case report An 80-year-old man developed rhabdomyolysis during treatment with atorvastatin. The man had a history of chronic bronchitis, emphysema, chronic heart failure, chronic atrial fibrillation, and type 2 diabetes mellitus, and was on 5 years of medication including aspirin, metoprolol, benazepril [benapril], and insulin. He was admitted to the infection center due to chronic bronchitis with a superimposed acute infection. He presented to infection centre of the hospital with chronic bronchitis and superimposed acute infection. Initially, he was treated with cefathiamidine, ambroxol, furosemide, spironolactone, and digoxin. On the eighth day, oral atorvastatin 20mg every night [indication not stated] and warfarin were initiated after consultation with a cardiologist. Next day following the drug adjustment, he developed pain in the right calf. Laboratory tests revealed a significant increase in creatine kinase (CK), myoglobin, and potassium levels. On the third and fifth days after taking atorvastatin, the CK levels was increased significantly. Based on his symptoms and laboratory findings, he was diagnosed with rhabdomyolysis. The man’s atorvastatin treatment was discontinued, and IV fluids were started on the 12th day. His hyperkalemia was controlled until the potassium level was normalised. Although the treatment was not completed, as per his request, he was discharged on the 14th day while still being in poor general condition. Later he was lost to follow-up. Xiao M, et al. Sudden rhabdomyolysis in an elderly patient after single atorvastatin dose: The need for early and frequent creatine kinase monitoring in high-risk patients. 803500149 SAGE Open Medical Case Reports 8: no pagination, Jan 2020. Available from: URL: http://doi.org/10.1177/2050313X20919623
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Reactions 5 Sep 2020 No. 1820
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