Behavioural changes with fluticasone propionate in children
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Behavioural changes with fluticasone propionate in children The Netherlands Pharmacovigilance Centre Lareb has received 17 reports of behavioural changes in children associated with the use of inhaled fluticasone propionate (n = 13) or salmeterol/fluticasone propionate (4). According to Lareb, in 11 cases, symptoms disappeared when fluticasone propionate was withdrawn. A positive rechallenge was observed in one case. Lareb states that 6 patients who had received fluticasone propionate only also received salbutamol; however, in all but one case, the reporter did not see a causal relationship between the adverse drug reaction and salbutamol. These results, say Lareb, support "our theory that fluticasone is responsible for the behavioural changes in the children." Lareb says that psychiatric effects have also been reported in association with the use of oral corticosteroids and inhaled budesonide, which raises the possibility of a group effect. Lareb. Fluticasone inhalation and behavioural changes in children. Internet Document : [5 pages], Jan 2007. Available from: URL: http:// 801013860 www.lareb.nl
0114-9954/10/1136-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 27 Jan 2007 No. 1136
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