Cotrimoxazole
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Hypersensitivity and hyponatremia: 2 case reports In a study of 188 patients, presented between September 2010 and April 2018, two patients [ages and sexes not stated] were described, who developed hypersensitivity reaction (n=1) or hyponatremia (n=1), while receiving cotrimoxazole for prophylaxis against pneumocystis pneumonia (PCP) [routes, dosages, durations of treatments to reactions onsets and outcomes not stated]. The patients, who had systemic lupus erythematosus, received cotrimoxazole [trimethoprim/sulfamethoxazole] for PCP prophylaxis. One of the 2 patients was receiving concomitant azathioprine. However, the patients developed hypersensitivity reaction (n=1) or hyponatremia (n=1) due to cotrimoxazole, requiring hospitalisation. Cotrimoxazole was withdrawn. Goto M, et al. Incidences of adverse effects and disease flare due to pneumocystis pneumonia prophylaxis with trimethoprim/ sulfamethoxazole in systemic lupus erythematosus patients. Annals of the Rheumatic Diseases 79 (Suppl.): 1047 abstr. SAT0208, Jun 2020. Available from: URL: https://ard.bmj.com/content/79/Suppl_1/1047.1 803516260 [abstract]
0114-9954/20/1831-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 21 Nov 2020 No. 1831
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