DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-
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ORIGINAL ARTICLE
DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR‑137 and miR‑15a dependent manner Sepideh Razi1 · Asieh Sadeghi2 · Zeynab Asadi‑Lari3 · Kevin J. Tam4 · Elham Kalantari1 · Zahra Madjd1,2,5 Received: 15 July 2020 / Accepted: 16 September 2020 © Springer Nature Switzerland AG 2020
Abstract Cancer stem cells (CSCs) are thought to be a major player in tumor initiation, progression, and metastasis. Targeting CSCs for elimination presents a promising therapeutic strategy; however, this approach will require a stronger understanding of CSC biology and identification of CSC-specific markers. The present study was conducted to examine the correlation between DCLK1 and miR-137 and miR-15a levels in colorectal cancer. A total of 222 samples, including 181 colorectal cancer specimens, 24 adenomatosis, and 17 non-adenomatosis colonic polyps, were stained for DCLK1 expression using immunohistochemistry. Also, expression of miR-137 and miR-15a was assessed in colorectal cancer with high and low DCLK1 expression levels. Most colorectal cancer specimens (76%) showed strong expression of DCLK1, whereas only 21% of adenomatous and none of non-adenomatous colonic polyps showed strong DCLK1 expression. A significant difference in DCLK1 expression was found between colorectal cancer, adenomatous, and non-adenomatous colonic polyps (P
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