Detection of cancer affected cell using Sagnac interferometer based photonic crystal fiber refractive index sensor
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Detection of cancer affected cell using Sagnac interferometer based photonic crystal fiber refractive index sensor Md. Aslam Mollah1 · Rownok Jahan Usha1 · Sanjida Tasnim1 · Kawsar Ahmed2 Received: 24 March 2020 / Accepted: 8 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The light interaction with the cell of any part or organ of the body gives useful information regarding the changes in optical properties for different cells. A photonic crystal fiber, selectively filled by the sample cell is proposed to detect the cancer cell based on the refractive index (RI). Upon considering the change of optical properties of the proposed fiber due to different RI of normal and cancer cell, sensitivities are attained of 11,428.57, 17,142.85, 31,428.57, and 34,285.71 nm/RIU for Jurkat, PC12, MCF-7, and MDA-MB-231 cell from the transmission spectrum obtained by the Sagnac interferometer phenomena. Keywords Photonic crystal fiber · Cancer cell · Sagnac interferometer · Optical sensor
1 Introduction Nowadays, cancer is one of the most severe disease in the world, for human growth which has become a great problem. Cancer is a group of different diseases more than 100 in number and it can be developed at almost any part or organ of the body. It is the second leading cause for death all over the world. Statistics says that, approximately 9.6 million deaths occurred globally for cancer in 2018, and the rate is increasing day by day (World health organization, Cancer 2018). However, if the detection of cancerous cell is possible at the early stage, at least the rate of death due to cancer can be decreased with current developed treatment and medications. Hence, research on early detection of cancer cell has been intensified throughout the globe over the last few decades. L. Clark et al. described the first biosensor which is able to detect the glucose level in blood (Clark et al. 1987). From then, plenty of works have been done to detect the cancer cells of different part of human body. In the early stage, cancer cell detection process was limited to different methods such as electro-chemical (Li et al. 2010), immune-chemistry (Li et al. 2013), molecular level (Neugebauer et al. 2010), Raman spectroscopy measurement (Liu et al. 2014), and micro-fluid devices (Hajba and Guttman 2014). * Kawsar Ahmed [email protected]; [email protected]; [email protected] 1
Department of Electronics & Telecommunication Engineering, Rajshahi University of Engineering & Technology, Rajshahi, Bangladesh
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Group of Biophotomatiχ, Department of Information and Communication Technology, Mawlana Bhashani Science and Technology University, Santosh, Tangail 1902, Bangladesh
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After that farther improvement has been done in detection of cancer cell through photo-thermal effect of nanocomposite (Zhou et al. 2016), 2D photonic crystal gratings (Sharma et al. 2015), photonic crystal sensor coated by nanocomposite material (Ramanujam e
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