Effect of Glutaraldehyde on Properties of Membranes Prepared from Fish Scale Collagen
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aldehyde on Properties of Membranes Prepared from Fish Scale Collagen Zhefeng Xu, Toshiyuki Ikoma, Tomohiko Yoshioka, Motohiro Tagaya, Satoshi Motozuka, Rena Matsumoto, Toshimasa Uemura and Junzo Tanaka MRS Proceedings / Volume 1418 / 2012 DOI: 10.1557/opl.2012.396
Link to this article: http://journals.cambridge.org/abstract_S194642741200396X How to cite this article: Zhefeng Xu, Toshiyuki Ikoma, Tomohiko Yoshioka, Motohiro Tagaya, Satoshi Motozuka, Rena Matsumoto, Toshimasa Uemura and Junzo Tanaka (2012). Effect of Glutaraldehyde on Properties of Membranes Prepared from Fish Scale Collagen. MRS Proceedings,1418, mrsf111418mm0604 doi:10.1557/opl.2012.396 Request Permissions : Click here
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Mater. Res. Soc. Symp. Proc. Vol. 1418 © 2012 Materials Research Society DOI: 10.1557/opl.2012.396
Effect of Glutaraldehyde on Properties of Membranes Prepared from Fish Scale Collagen Zhefeng Xu1, Toshiyuki Ikoma1, Tomohiko Yoshioka1, Motohiro Tagaya1,*, Satoshi Motozuka1, 2, Rena Matsumoto3, Toshimasa Uemura3 and Junzo Tanaka1 1 Department of Metallurgy and Ceramics Science, Tokyo Institute Technology University, O-okayama 2-12-1, Meguro-ku, Tokyo 152-8550 JAPAN *Present address: Department of Materials Science and Technology, Nagaoka University of Technology, Kamitomioka 1603-1, Nagaoka, Niigata 940-2188, JAPAN 2 Department of Mechanical Engineering, Gifu National College of Technology, Kamimakuwa 2236-2, Motosu-si, Gifu 501-0495, JAPAN 3 Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology, Central 4, 1-1-1 Higashi, Tsukuba, Ibaraki 3-5-8562, JAPAN ABSTRACT Collagen fibril membranes (CFMs) with a high mechanical property were fabricated with a lateral face evaporation method, in which type I atelocollagen extracted from tilapia scales was used. The density and thickness of the CFM obtained were 0.51 ± 0.04 mg/cm3 and 50 ± 5 μm. The collagen fibrils in the CFM had a similar periodic stripped pattern of 67 nm with native collagen fibrils. The CFM was crosslinked in gaseous glutaraldehyde for different duration in order to increase the mechanical property. The crosslinking degrees of the CFMs analyzed by free amino groups gradually increased to 70.3 % against the exposure duration until 6 hours, and reached a plateau. The denaturation temperatures of the CFMs with the crosslinking degrees at 20.4 % to 43% were linearly increased from 49°C to 75°C. The tensile strength of the CFMs was slightly improved until the crosslinking degree at 33.3 % and then the tensile strength rapidly increased to be 68 MPa. It was suggested that a percolation phenomenon took place in the CFMs by crosslinking of collagen fibrils with polymerized GA molecules. INTRODUCTION Type I collagen has biocompatibility [1], biodegradability [2], and excellent cellular adhesion property [3]. Thereby, the collagen has been used in the fields of biomedical devices, food, and cosmetics [4-7]. The application of collagen extrac
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