Elevated serum levels of interleukin-17A in children with autism
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AL-Ayadhi and Mostafa Journal of Neuroinflammation 2012, 9:158 http://www.jneuroinflammation.com/content/9/1/158
RESEARCH
Open Access
Elevated serum levels of interleukin-17A in children with autism Laila Yousef AL-Ayadhi1 and Gehan Ahmed Mostafa1,2,3*
Abstract Background: The T-helper (Th)1/Th2 dichotomy dominated the field of immune regulation until interleukin (IL)-17-expressing T cells (Th17) were proposed to be a third lineage of helper T cells, the key players in the pathogenesis of autoimmune disorders. Autoimmunity to brain tissue may play a pathogenic role in autism. IL-17A is a pro-inflammatory cytokine that has been shown to play an important role in various autoimmune neuroinflammatory diseases. The aim of this study was to measure serum levels of IL-17A in relation to the degree of the severity of autism. Methods: Serum IL-17A levels were measured by ELISA in 45 children with autism and 40 matched healthy controls. Results: Children with autism had significantly higher serum IL-17A levels than healthy controls (P 0.05). No significant crossreactivity or interference was seen. Statistical analysis
The results were analyzed by commercially available software package (Statview, Abacus Concepts Inc.,
AL-Ayadhi and Mostafa Journal of Neuroinflammation 2012, 9:158 http://www.jneuroinflammation.com/content/9/1/158
Berkley, CA, USA). The data were non-parametric, thus they are presented as median and interquartile range (IQR; 25th to 75th percentile). Patients were considered to have raised serum IL-17A if the levels were above the highest cut-off values (1.73 pg/ml), which was the 95th percentile of the serum IL-17A levels of healthy controls, as the distribution of the data was non-parametric. The Mann–Whitney test was used for comparison between these data, and the χ² test was used for comparison between qualitative variables of the studied groups. Spearman’s rho correlation coefficient ‘r’ was used to determine the relationship between different variables. For all tests, P
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