Endothelial Signaling in Development and Disease
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, l
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Mirko HH Schmidt • Stefan Liebner Editors
Endothelial Signaling in Development and Disease
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Editors Mirko HH Schmidt Microscopic Anatomy and Neurobiology Johannes Gutenberg University School of Medicine Mainz, Germany
Stefan Liebner Institute of Neurology Goethe University Frankfurt School of Medicine Frankfurt, Germany
ISBN 978-1-4939-2906-1 ISBN 978-1-4939-2907-8 (eBook) DOI 10.1007/978-1-4939-2907-8 Library of Congress Control Number: 2015944714 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc., in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein, or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Foreword
How blood and lymphatic vessels form functional networks that are adapted to effectively meet the metabolic and homeostasis requirement of organs and the organism as a whole is a most fascinating question that stimulates the rapidly growing field of vascular biology research. As we appreciate the complexity of cellular and molecular interactions, the intricacies of localized functional requirements, and the heterogeneity of the cellular constituents that form blood and lymphatic vessels, the growing number of open questions may seem overwhelming. Advanced genetic model systems to selectively study gene functions in the endothelial cells lining blood and lymphatic vessels, as well as the supporting smooth muscle cells, have helped to chart key pathways controlling the formation and differentiation of vascular networks. Rapidly improving imaging methodology, functional labeling, and organotypic dynamic in vitro assays help to unravel morphogenic principles of sprouting, lumen formation, stabilization, and regression. Signaling networks that have traditionally been mapped in cell culture now take shape in vivo as we see genetic models dissect individual residues in signaling receptors, and quantitative assessment of protein–protein com
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