Environmental Radiation Effects on Mammals A Dynamical Modeling Appr
This text is devoted to the theoretical studies of radiation effects on mammals. It uses the framework of developed deterministic mathematical models to investigate the effects of both acute and chronic irradiation in a wide range of doses and dose rates
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Olga A. Smirnova
Environmental Radiation Effects on Mammals A Dynamical Modeling Approach
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Dr. Olga A. Smirnova Research and Technical Center of Radiation-Chemical Safety and Hygiene Shchukinskaya str. 40 123182, Moscow Russian Federation [email protected]
ISBN 978-1-4419-7212-5 e-ISBN 978-1-4419-7213-2 DOI 10.1007/978-1-4419-7213-2 Springer New York Dordrecht Heidelberg London c Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Dedicated to my advisor, N.V. Stepanova
Preface
The monograph is devoted to the theoretical studies of radiation effects on mammals. It summarizes the results obtained by the author over the past 30 years, most of them being of high priority. In the course of these studies, a single approach to the modeling of radiation effects on mammals has been elaborated. Specifically, in the framework of the developed deterministic mathematical models, the effects of both acute and chronic irradiation in a wide range of doses and dose rates on vital body systems (hematopoiesis, small intestine, and humoral immunity), as well as on the development of autoimmune diseases, are investigated. The radiation effects on the mortality dynamics in homogeneous and nonhomogeneous (in radiosensitivity) mammalian populations are also studied by making use of the developed stochastic models. The most appealing feature of these mortality models consists of the fact that they account for the intrinsic properties of the exposed organism. Namely, within these models the stochastic biometrical functions are calculated proceeding from statistical characteristics and dynamics of the respective critical body system (hematopoiesis or small intestine). The performed theoretical investigations contribute to the development of the system and quantitative approaches in radiation biology and ecology. These studies elucidate the major regulatory mechanisms of the damage and recovery processes running in the vital body systems of exposed mammals and reveal the key parameters characterizing the processes. Proposed explanations of a number of nonlinear effects of low-level single/chronic irradiation on the vital body systems, on the organism as a whole, and on a nonhomogeneous mammalian population are
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