Expression and clinical significance of stem cell marker CD133 in human neuroblastoma
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Expression and clinical signicance of stem cell marker CD133 in human neuroblastoma Qiang-Song Tong, Li-Duan Zheng, Shao-Tao Tang, Qing-Lan Ruan, Yuan Liu, Shi-Wang Li, Guo-Song Jiang, Jia-Bin Cai Wuhan, China
Original article 58
Background: Recent evidences indicate that CD133, a kind of transmembrane protein, can be used as a marker to isolate stem cells from tumors originating from neural crest. This study was undertaken to explore the expression and clinical signicance of stem cell marker CD133 in neuroblastoma (NB). Methods: Immunohistochemical staining was used to detect the expression of CD133 in 32 patients with NB and 8 patients with ganglioneuroblastoma (GNB). The relationships were analyzed among CD133 expression, international neuroblastoma staging system (INSS) stages, pathological classication, and postoperative survival time of NB patients. Results: The expression rates of CD133 in NB and GNB were 46.9% (15/32) and 37.5% (3/8) respectively, mainly in cytoplasm of neuroblastoma cells. The expression rates of stage 1-2, stage 3-4 and stage 4S were 30.7%, 57.9% and 37.5%, respectively. The differences in various stages were signicant (P
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