Expression of Pro-Inflammatory Cytokines and the Risk of Intracranial Aneurysm
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Expression of Pro-Inflammatory Cytokines and the Risk of Intracranial Aneurysm Hai-Feng Zhang,1 Ming-Guang Zhao,1 Guo-Biao Liang,1,2 Zhen-Quan Song,1 and Zhi-Qing Li1
Abstract—Intracranial aneurysm (IA) lingers as a potentially devastating clinical problem, in which inflammation acts as a critical contributor to the pathogenesis of this disease. Cytokines play a major role in regulating inflammation. The aim of this study was to gain insight in the inflammatory response in IA by assessing plasma cytokine profiles. Plasma levels of 10 cytokines were quantified by multiplex protein arrays in 66 patients with IA and 78 healthy controls. Results showed that plasma level of interleukin 1 beta (IL-1β) was 2.4-fold higher in patients than in controls (p
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