Finasteride
- PDF / 141,935 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 9 Downloads / 166 Views
1
S
Poor seminal quality: 3 case reports Three men developed poor seminal quality during treatment with finasteride for hair loss [duration of therapy to reaction onset not stated]. Patient 1, a 36-year-old man, was referred to a male infertility clinic after 3 years of sexual intercourse without conception. He reported taking finasteride 1 mg/day for 5 years. Seminal samples, obtained during finasteride treatment, showed azoospermia. One year after finasteride cessation, his spermatogenesis had recovered. However, his semen parameters were not within the normal parameters. He had averages of 89.64% immaturity, 65.34% necrosis, 13.33% apoptosis with an average of 387.67 healthy sperm. He had higher sex chromosome disomies and diploidies than controls. Patient 2, a 29-year-old man, was referred to a male infertility clinic after 3 years of sexual intercourse without conception. He reported taking finasteride 1 mg/day for 5 years. Three seminal samples, obtained during finasteride therapy, revealed normal sperm concentration but severely decreased rapid and slow progressive motility (average of 14%). Sperm ultrastructural analysis showed high necrosis (50.51%). He had reduced number of sperm probably without ultrastructural defects (average of 134,27 healthy sperm), indicating severe fertility problems. He also had elevated frequencies of 18XY disomy and 1818XY diploidy. One year after finasteride cessation, he had improved sperm motility (33.33%) and his number of healthy sperm had increased to nearly normal levels (1 360 513); his percentage of sperm necrosis was also decreased (31.80%). Patient 3, a 34-year-old man, was referred to a male infertility clinic after 3 years of sexual intercourse without conception; he had fathered a child 1 year before finasteride therapy. He reported taking finasteride 1 mg/day for 5 years. Three seminal samples, obtained during finasteride treatment, showed normal sperm concentration but severely decreased rapid and slow progressive motility (average of 17.77%). Sperm ultrastructural analysis showed high necrosis (46.54%). He had reduced number of sperm probably without ultrastructural defects (average of 398,701 healthy sperm), indicating severe fertility problems. He had higher frequencies of 18XY disomy and1818XX and 1818XY diploidies, than controls. One year after finasteride cessation, he had improved motility (26.67%) and his number of healthy sperm had increased to almost 2 million. Collodel G, et al. Spermatozoa and chronic treatment with finasteride: a TEM and FISH study. Archives of Andrology 53: 229-233, No. 4, Jul-Aug 2007 801091882 Italy
0114-9954/10/1176-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 3 Nov 2007 No. 1176
Data Loading...
