International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)
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ORIGINAL PAPER
International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen‑ECT‑ic) Takahiro Soda1 · Declan M. McLoughlin2 · Scott R. Clark3 · Leif Oltedal4,28 · Ute Kessler4,5 · Jan Haavik5,6 · Chad Bousman7 · Daniel J. Smith8 · Miquel Bioque9 · Caitlin C. Clements10 · Colleen Loo11,12 · Fidel Vila‑Rodriguez13 · Alessandra Minelli14 · Brian J. Mickey15 · Roumen Milev16,17 · Anna R. Docherty15 · Julie Langan Martin8 · Eric D. Achtyes18 · Volker Arolt19 · Ronny Redlich19 · Udo Dannlowski19 · Narcis Cardoner20 · Emily Clare21 · Nick Craddock22 · Arianna Di Florio22 · Monika Dmitrzak‑Weglarz23 · Liz Forty22 · Katherine Gordon‑Smith24 · Mustafa Husain25 · Wendy M. Ingram26 · Lisa Jones24 · Ian Jones22 · Mario Juruena27 · George Kirov22 · Mikael Landén29 · Daniel J. Müller30 · Axel Nordensköld31 · Erik Pålsson29 · Meethu Paul21 · Agnieszka Permoda33 · Bartlomiej Pliszka27 · Jamie Rea21 · Klaus O. Schubert3,32 · Joshua A. Sonnen33 · Virginia Soria34 · Will Stageman21,35 · Akihiro Takamiya36 · Mikel Urretavizacaya34 · Stuart Watson21,35 · Maxim Zavorotny37 · Allan H. Young27 · Eduard Vieta9 · Janusz K. Rybakowski33,38 · Massimo Gennarelli14,39 · Peter P. Zandi40 · Patrick F. Sullivan1,41,42 · Bernhard T. Baune19,43,44 Received: 11 August 2019 / Accepted: 16 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic studies of patients at the most severe end of the depressive disorder spectrum, those with treatment-resistant depression and who are prescribed electroconvulsive therapy (ECT), could lead to a better understanding of the genetic underpinnings of depression. Despite ECT being one of the most effective forms of treatment for severe depressive disorders, it is usually placed at the end of treatment algorithms of current guidelines. This is perhaps because ECT has controlled risk and logistical demands including use of general anaesthesia and muscle relaxants and side-effects such as short-term memory impairment. Better understanding of the genetics and biology of ECT response and of cognitive side-effects could lead to more personalized treatment decisions. To enhance the understanding of the genomics of severe depression and ECT response, researchers and ECT providers from around the world and from various depression or ECT networks, but not limited to, such as the Psychiatric Genomics Consortium, the Clinical Alliance and Research in ECT, and the National Network of Depression Centers have formed the Genetics of ECT International Consortium (Gen-ECT-ic). Gen-ECT-ic will organize the largest clinical and genetic collection to date to study the genomics of severe depressive disorders and response to ECT, aiming for 30,000 patients worldwide using a GWAS approach. At this stage it will be the largest genomic study on treatment response in depression. Retrospective data a
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