Irinotecan
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Fatal pneumonitis in an elderly patient: case report An 81-year-old man with small-cell lung cancer received four cycles of chemotherapy with cisplatin and etoposide before commencing irinotecan [dosage not stated]. He was hospitalised with dyspnoea after three infusions, and ground-glass opacities were observed bilaterally on CT scan. Antibacterials and corticosteroids were started, with a rapid recovery. Irinotecan was resumed, but he was hospitalised with respiratory failure 2 weeks after his fourth infusion. Mechanical ventilation was initiated, and chest Xray showed diffuse interstitial infiltrates and dense infiltrates on his right side. He subsequently died, despite extensive treatment. Author comment: "An immunopathological mechanism has been suggested with histopathologic evidence of diffuse alveolar damage/fibrosis." Chandak TR, et al. Irinotecan(CPT-II)-induced fatal pulmonary toxicity. 106th International Conference of the American Thoracic Society : A2928, 14 May 2010. 803022409 Available from: URL: http://www.thoracic.org [abstract] - USA
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Reactions 26 Jun 2010 No. 1307
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