Leishmania
Leishmania parasites cause a diverse group of diseases endemic to many tropical and subtropical regions of the world. This volume seeks to bring together recent research on cell and molecular biology of Leishmania with chapters on the host response to inf
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Response to L. amazonensis 155, 157, 158 Response to L. major Nitric oxide production 152,160 Response to L. mexicana 157,158 Response to L. pifanoi 158 T cell subsets and human infection 159, 161, 162 T cell subsets and murine infection 151-158 Immune response to visceral infection Chemokines and resistance 142 Interleukin IL-I0 138, 140, 142, 143, 145 Interleukin IL-12 138, 14, 144 TGF~ 140, 143, 145 Role ofCTLA-4 143, 145 Role ofCD4+ T cells 140, 142, 144, 145 Role of CD8+ T cells 142, 143 TNFa 152,161-162 Immunopathology 40, 41 Th2 cells and human infection 138 Hamster model 145, 146
Leishmania Classification 2 Life cycle 4 Tissue distribution and disease 4, 5 Leishmania amazonensis 3, 14, 15, 16,19,20,35,89,92,96,97, 98 Leishmania aethiopica 3, 7, 34, 119, 136
192 Leishmania arabica 3
96,98,140, 144, 149-159, 169, 171-181
Leishmania archibaldi 3 Leishmania mexicana 3, 7, 14-19, Leishmania aristidesi 3, 20 Leishmania braziliensis 3, 5,
117, 119, 143,157,158,171,172
2~35,4~64,76,83,
7,14-16,21,22,35,46,49,50, 54,89,155,157,158,160
Leishmania. naiffi 3, 14, 15,25,
Leishmaniachagasi 3,14-17,35,
Leishmania panamensis 2,3,5, 7,
46,50,64, 115, 143,171
14, 15, 19,22-24,27,35,63, 136, 159
13~
139, 141,
Leishmania colombiensis 14,35 Leishmania deanei 3, 14,26 Leishmania donovani 3-6, 17, 34, 38,45,46,49,62-66, 75, 77, 79, 80,82,89,91,92,98,104,106, 107,115,116,120-124,137,138, 140, 141, 143-145, 155
Leishmania. enriettii 3, 14,25, 76,77,84
Leishmania. gerbilli 3 Leishmania guyanensis 2,3,7, 1416, 35 159
Leishmania. hertigi 3, 15,26 Leishmania infantum 2-6, 14-17, 34,35,38,39,45-50,52,54,115, 121,137, 140
Leishmania killicki 3 Leishmania iainsoni 14 Leishmania major 3,5, 7, 14, 15, 21,34,38,49,61-68,82,89-92,
35
Leishmania peruviana 3, 4, 7, 16, 22,23,35,46,49
Leishmania tropica 3, 4, 6, 7, 34, 38,49,63,64,116,117,119, 123, 158
Leishmania. turanica 2, 3, 7 Leishmania surface receptors GP63 61,63, 89,90, 92-94, 123, 171,172 GP63 expression by promastigotes 63 GP63 in sand fly midgut infection 64,65 Lipophosphoglycan 61-66, 90, 92,96,104 LPG interaction with sand fly midgut 65,66 Role in LPG in metacyclogenesis 66,67 Structure of LPG 62, 65
Macrophage and infection Complement and complement receptor 87-93, 97, 106 Fc receptor 95,96, 158, 160 Expression of Class II 106 IL-12 production 98, 105
193 Macrophage activation by imidazoquinolines 108 Macrophage gene expression 106, 107
Macrophage viability 106, 107 Phagolysosome 104 Membrane transporters Biopterin transporter 80, 81 GDP-mannose transporter 79, 80 GDP-mannose association with LPG 79,80 Glucose transporters 76-79, 84 Mode of activity 77, 78 Structure 77 Myo-inositol transporter79 Nucleoside transporter 81-83 Vaccination L. amazonensis 172, 178 L. chagasi 171 L. majorl69, 171-183 L. mexicana 171-172
Vaccine adjuvants 175-179 IL-12 171, 175-177, 179-183 Vaccine antigens LACK 173, 175, 176, 180 LeIF 174,178 LMSTlI 178, 180-183 TSA 178,180-183 Vaccination with DNA 173-179 Vector Control 37-39 Infection in sand flies Parasite transmission 66-
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