Membrane Transporters in Drug Discovery and Development Methods and
Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical meth
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MO L E C U L A R BI O L O G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
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Membrane Transporters in Drug Discovery and Development Methods and Protocols
Edited by
Qing Yan PharmTao, Santa Clara, California, USA
Editor Qing Yan PharmTao PO Box 5672 Santa Clara , CA 95056 -5672 USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-699-3 e-ISBN 978-1-60761-700-6 DOI 10.1007/978-1-60761-700-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010923408 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. About 30% of current clinically marketed drugs are targeting membrane transporters or channels. This book provides various practical methodologies of the ongoing research on membrane transporters, especially applications of transporter technologies in drug discovery and development. To provide readers the most up-to-date information, new and useful fields and methodologies are embraced in this volume, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time PCR. Transporter studies in drug discovery and development for various diseases are discussed, such as neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Pharmacogenomics and systems biology studies of membrane transporters are useful in drug discovery and in predicting drug responses in the clinic. In this volume, the current status of these emerging fields in relevance to transporter studies is reviewed and the ke
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