Metal-Doped Barium Sulphate Nanoparticles Decorated with Gelatin as Antibacterial Agents
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ORIGINAL PAPER
Metal-Doped Barium Sulphate Nanoparticles Decorated with Gelatin as Antibacterial Agents Balwinder S. Sooch1 • Manpreet K. Mann1 • Manvi Sharma1 Received: 4 March 2020 Ó Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Nanoparticles are gaining a new impetus in the field of medicine because of their potential to overcome core problems of drug efficacy. Amongst inorganic nanoparticles, barium sulphate in nano form is achieving wide attention due to its valuable applications. Despite the several advantages of barium sulphate nanoparticles, there is a major difficulty in their preparation and stability in the medium, as they belong to poorly soluble particles group. Hence, bearing in mind the synthesis barriers associated with these nanoparticles, a modified methodology has been designed for the synthesis of nanoparticles by capping them with gelatin. In addition, to enhance their physico-chemical properties and antimicrobial efficacy, BaSO4 nanoparticles were doped with four different metals. The synthesized nanoparticles were characterized through UV–Visible spectra, X-Ray Diffraction patterns, Dynamic Light Scattering, Field Emission Scanning Electron Microscopy analysis. Their antimicrobial potential and cytotoxicity through mitogenic response was also evaluated. These doped nanoparticles have shown enhanced properties in their structure (size reduction from micro to nano, dispersibility in the medium, non-aggregation etc.) and antimicrobial efficiency than its bulk counterparts. To the best of our knowledge, this is the first report on antimicrobial potential of synthesized metal-doped barium sulphate nanoparticles stabilized with gelatin. Graphic Abstract
& Balwinder S. Sooch [email protected] 1
Enzyme Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala-147002, Punjab, India
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Keywords Barium Sulphate Gelatin Doping Capping Antibacterial Nanoparticles Abbreviations BaSO4 Barium Sulphate CFU/ml Colony Forming Units/milliliter Co Cobalt Cu Copper DLS Dynamic Light Scattering DMSO Dimethyl Sulfoxide FE-SEM Field Emission Scanning Electron Microscopy Mn Manganese MTCC Microbial Type Culture Collection and Gene Bank MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide) ppm Parts Per Million XRD X-Ray Diffraction Zn Zinc
Introduction Nanoparticles are gaining a new impetus in the field of pharmaceuticals and medicine as these are widely used as drugs and drug delivery systems. This importance of nanoparticles is because of their potential to overcome some core problems of drug efficacy by allowing the passage through narrow biological barriers and effective targeted delivery [1–3]. Inorganic nanoparticles are generally synthesized by the crystallization of inorganic salts through a variety of traditional and advanced methods, but still the simple precipitation method has several advantages over others such as low cost, good reproducibility and mild re
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