Molecular Mechanisms in Legionella Pathogenesis

Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets

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Hubert Hilbi Editor

Molecular Mechanisms in Legionella Pathogenesis

Current Topics in Microbiology and Immunology Volume 376

Series Editors Klaus Aktories Medizinische Fakultät, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany Richard W. Compans Department of Microbiology and Immunology, Emory University, 1518 Clifton Road, CNR 5005, Atlanta, GA 30322, USA Max D. Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 Clifton Road, Atlanta, GA 30322, USA Jorge E. Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT 06536-0812, USA Yuri Y. Gleba ICON Genetics AG, Biozentrum Halle, Weinbergweg 22, 06120 Halle, Germany Tasuku Honjo Faculty of Medicine, Department of Medical Chemistry, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan Yoshihiro Kawaoka School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA Bernard Malissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France Fritz Melchers Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany Michael B. A. Oldstone Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Rino Rappuoli Novartis Vaccines, Via Fiorentina 1, Siena 53100, Italy Peter K. Vogt Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-239, La Jolla, CA 92037, USA Honorary Editor: Hilary Koprowski Biotechnology Foundation, Inc., Ardmore, PA, USA (deceased)

For further volumes: http://www.springer.com/series/82

Hubert Hilbi Editor

Molecular Mechanisms in Legionella Pathogenesis Responsible Series Editor: Klaus Aktories

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Editor Hubert Hilbi Max von Pettenkofer Institute Ludwig-Maximilians University München Munich Germany

ISSN 0070-217X ISBN 978-3-642-40590-7 DOI 10.1007/978-3-642-40591-4

ISSN 2196-9965 (electronic) ISBN 978-3-642-40591-4 (eBook)

Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013948854 Ó Springer-Verlag Berlin Heidelberg 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the