Olanzapine
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Olanzapine Fatal pulmonary embolism: 6 case reports
Six patients developed fatal pulmonary embolism during treatment with olanzapine [dosage and duration of treatment before reaction onset not stated for any patients; therapeutic indication not stated for five patients]. Characteristics for the six patients are described in Table 1. Of the six patients, a 47-year-old woman (patient 1), who had schizophrenia, a body mass index of 19 and was treated with lithium and, most recently olanzapine, was found dead. Her autopsy was remarkable for acute pulmonary embolism in the left main pulmonary artery which extended into the lobar branches; an adherent thrombus in the left popliteal vein was revealed when leg vessels were dissected. The remainder of the woman’s autopsy revealed there no evidence of natural disease or trauma. The presence of olanzapine was confirmed by toxicology, but no other substances were found; there were no other risk factors for pulmonary embolism. Two of the other six patients had risk factors for pulmonary embolism. Factor V Leiden and prothrombin mutation testing was negative all in patients.
Table 1. Patient characteristics Patient
Sex
Age (years)
BMI
Risk factors
1 2 3 4
Female Female Male Female
47 26 54 42
19 31.8 25.2 38
5 6
Female Female
63 47
24.7 37.7
None None None Obesity/ recent ankle fracture None Obesity
BMI = body mass index
Kannan R, et al. Olanzapine: a new risk factor for pulmonary embolus? American Journal of Forensic Medicine and Pathology 29: 368-370, No. 4, Dec 2008 801126038 USA
0114-9954/10/1232-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 13 Dec 2008 No. 1232
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