Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective st
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ORIGINAL CONTRIBUTION
Possible association of vitamin D status with lung involvement and outcome in patients with COVID‑19: a retrospective study Alireza Abrishami1 · Nooshin Dalili2 · Peyman Mohammadi Torbati3 · Reyhaneh Asgari4 · Mehran Arab‑Ahmadi5 · Behdad Behnam6 · Morteza Sanei‑Taheri7,8 Received: 27 May 2020 / Accepted: 6 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Vitamin D deficiency has been reported as a key factor in the development of infectious diseases such as respiratory tract infections and inflammatory processes like acute respiratory distress syndrome. However, the impact of vitamin D on the severity and outcome of COVID-19 is still not fully known. Herein, we aimed to evaluate the prognostic role of serum vitamin D concentration on the extent of lung involvement and final outcome in patients with COVID-19. Methods Seventy-three subjects with confirmed diagnosis of COVID-19 were investigated in this study. The patients had been admitted to our academic hospital from February 28, 2020 to April 19, 2020. Demographic and clinical data, serum 25(OH)D levels, and findings of initial chest computed tomography were recorded. Linear and binary logistic regression, cox regression and ROC curve tests were used for statistical analysis. Results The mean age of patients was 55.18 ± 14.98 years old; 46.4% were male. Mean serum 25(OH)D concentration was significantly lower in the deceased (13.83 ± 12.53 ng/ mL compared with discharged patients (38.41 ± 18.51 ng/mL) (P
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