Principles of Cancer Treatment and Anticancer Drug Development
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy a
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Principles of Cancer Treatment and Anticancer Drug Development
Principles of Cancer Treatment and Anticancer Drug Development
Wolfgang Link
Principles of Cancer Treatment and Anticancer Drug Development
123
Wolfgang Link Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM) Madrid, Spain
ISBN 978-3-030-18721-7 ISBN 978-3-030-18722-4 https://doi.org/10.1007/978-3-030-18722-4
(eBook)
© Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
This book is dedicated to my wife, Ana
Preface
This book explains how current medicines against cancer work and how we find new ones. This is in a nutshell the content of the current book which is based on advanced classes in a master’s degree program on “Molecular Mechanisms of Cancer.” This postgraduate program includes learning modules on cell division and cell cycle, signal transduction, oncogenetic and oncogenomics, genetic toxicology, cell differentiation and stem cells, microenvironment, tumor progression, and clinical oncology. The learning module defeating cancer includes two main parts, one on cancer therapy and the second on drug development. The first part of Chap. 1 provides an introduction to the major problems we face when we treat malignant tumors in humans, setting the stage for Chap. 2 with a systematic overview over the current options of cancer therapy such as surgery, radiation, immunotherapy and chemotherapy and their corresponding modes of action. In particular, we focus on standard chemotherapeutic and targeted drugs and explain how they work. In Chap. 3, we cover intrinsic and acquired resistance mechanisms which represent the main obstacle to improve the clinical outcome of current c
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