Protein Scaffolds Design, Synthesis, and Applications
This volume provides a wide range of methods and protocols detailing various protein structures as platforms for building architectures with targeted application. Chapters guide the readers through exploiting a number of protein scaffolds including virus
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Andrew K. Udit Editor
Protein Scaffolds Design, Synthesis, and Applications
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Protein Scaffolds Design, Synthesis, and Applications
Edited by
Andrew K. Udit Department of Chemistry, Occidental College, Los Angeles, CA, USA
Editor Andrew K. Udit Department of Chemistry Occidental College Los Angeles, CA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7892-2 ISBN 978-1-4939-7893-9 (eBook) https://doi.org/10.1007/978-1-4939-7893-9 Library of Congress Control Number: 2018941577 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Proteins may be the ultimate scaffold for building molecular architectures: the varied chemical functionality of amino acid side chains coupled with the wide range possible in protein size makes it viable to generate a vast array of structures that differ either slightly or markedly in chemical and structural properties. These architectures help extremophiles tolerate harsh living conditions, allow marine organisms to stick stubbornly to ships, and impart a warm glow to bioluminescent organisms. Add to this the novel functionality imparted by incorporating unnatural amino acids, or targeted modifications utilizing site-specific bioconjugation methods, and it becomes clear that proteins are malleable platforms for myriad applications. Recognizing t
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