RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-
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Release-Active Dilutions of Diclofenac Enhance Anti-inf lammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model Sachin S. Sakat,1 Kamaraj Mani,1 Yulia O. Demidchenko,2 Evgeniy A. Gorbunov,2,3 Sergey A. Tarasov,2 Archna Mathur,1 and Oleg I. Epstein2
Abstract—The study was aimed to investigate the effect of technologically treated diclofenac (releaseactive dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6–8 weeks) divided into nine groups (n=10) were used. Anti-inflammatory activity was assessed at 1, 2, 3, 4, and 6 h after subplantar injection of carrageenan (0.1 ml of a 1 % solution in normal saline). Diclofenac alone was studied at 5 and 20 mg/kg, RAD of diclofenac alone at 7.5 ml/kg and their combination at 5 and 7.5 ml/kg, respectively. Diclofenac reduced (p
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