Role of T-Type Ca2+ Channels in Basal Insulin Release
Increases in plasma glucose concentration enhance the expression and activity of T-type Ca2+ channels in insulin-secreting pancreatic β-cells. The resulting elevation in T-type Ca2+ channel activity results in an elevation in the basal [Ca2+]i of β-cells.
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type Calcium Channels in Basic and Clinical Science
T-type Calcium Channels in Basic and Clinical Science
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Stephen W. Schaffer • Ming Li Editors
T-type Calcium Channels in Basic and Clinical Science
Editors Stephen W. Schaffer University of South Alabama School of Medicine Mobile, AL USA
Ming Li Department of Physiology Tulane University School of Medicine New Orleans, LA USA
ISBN 978-3-7091-1412-4 ISBN 978-3-7091-1413-1 (eBook) DOI 10.1007/978-3-7091-1413-1 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2014957411 # Springer-Verlag Wien 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
It has been 30 years since the initial characterization of T-type channel current by Armstrong and Matteson (1985) and 15 years since the molecular cloning of the three subtypes of the T-type Ca2+ channel by Perez-Reyes et al., Cribbs et al., and Lee et al. (1998, 1999). In the last decade much has been learned regarding the biophysics, biochemistry, physiology, and pharmacology of these channels, with information being gleaned from a wide range of studies varying from structure– function relationships to therapeutic applications. In this book, recent advances in T-type Ca2+ channel research are rev
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