Skeletal Muscle Density and Cognitive Function: A Cross-Sectional Study in Men
- PDF / 472,482 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 14 Downloads / 132 Views
ORIGINAL RESEARCH
Skeletal Muscle Density and Cognitive Function: A Cross‑Sectional Study in Men Sophia X. Sui1,6 · Lana J. Williams1 · Kara L. Holloway‑Kew1 · Natalie K. Hyde1 · Kara B. Anderson1 · Monica C. Tembo1 · Alex B. Addinsall1 · Sarah Leach2 · Julie A. Pasco1,3,4,5 Received: 9 February 2020 / Accepted: 15 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract We aimed to investigate cross-sectional associations between skeletal muscle density, a proxy measure for fatty infiltration into muscle, and cognition. Contributions from body fat mass, systemic inflammation and lifestyle were explored, as these factors have been identified in both muscle and cognitive deterioration. For 281 men (60–95 year) from the Geelong Osteoporosis Study, radial and tibial muscle density were measured using peripheral quantitative computed tomography. Body fat and appendicular lean mass were measured using dual-energy X-ray absorptiometry. Cognitive function was assessed for psychomotor function (DET), visual identification/attention (IDN), visual learning (OCL) and working memory (OBK) (CogState Brief Battery). Composite scores signified overall cognitive function (OCF). Higher scores represent poorer performance except for OCL and OCF. Regression analyses examined associations between muscle density and cognition; potential confounders included age, muscle cross-sectional area (CSA), body composition, lifestyle and serum markers of inflammation. Negative associations with age were evident for muscle density, all cognitive domains and OCF. Muscle density at both sites was positively associated with DET, OCL and OCF. After adjustment for age, the association persisted for DET (radius: B = − 0.006, p = 0.02; tibia: B = − 0.003, p = 0.04) and OCL (radius B = + 0.004, p = 0.02; tibia: B = + 0.005, p
Data Loading...
