Suppression and Regulation of Immune Responses Methods and Protocols

Over the past several years, a high diversity of regulatory cells and suppressive molecules has taken centre stage in the field of immunoregulation. In Suppression and Regulation of Immune Responses: Methods and Protocols, expert researchers highlight rec

  • PDF / 11,744,282 Bytes
  • 475 Pages / 504 x 720 pts Page_size
  • 6 Downloads / 183 Views

DOWNLOAD

REPORT


in

Molecular Biology™

Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK



For other titles published in this series, go to www.springer.com/series/7651

www

Suppression and Regulation of Immune Responses Methods and Protocols

Edited by

Maria Cristina Cuturi INSERM UMR 643, Nantes, France and

Ignacio Anegon INSERM UMR 643, Nantes, France

Editors Dr. Maria Cristina Cuturi INSERM UMR 643, Nantes, France [email protected]

Ignacio Anegon, MD INSERM UMR 643, Nantes, France [email protected]

ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-868-3 e-ISBN 978-1-60761-869-0 DOI 10.1007/978-1-60761-869-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010936185 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or ­dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, ­neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover Illustration Caption: The Yin/Yang image. In this case, the black represents immune response, and the white represents immune regulation. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

Dedication To my wonderful, unique and beloved family

v

www

Acknowledgments We would like to thank Mrs. Brenda Evans for her very efficient editorial assistance. We would also like to thank the support of RISET European program (http://www.risetfp6. org/), the program IMBIO (http://www.imbio.fr/accueil.html) from the Région Pays de la Loire, the Fondation Progreffe (http://www.progreffe.com/), and the Fondation Centaure (http://www.fondation-centaure.fr/).

vii

www

Preface “Le savant n’est pas l’homme qui fournit les vraies réponses, c’est celui qui pose les vraies questions.” Claude Lévi-Strauss

The immune system is able to mount an effective immune response to virtually any foreign antigen but does not react against self-components. One of the mechanisms for doing that is to create the largest repertoire of B and T cells able to recognize the most