Surface-Functionalizing Metal, Metal Oxide and Semiconductor Nanocrystals with a Multi-coordinating Polymer Platform
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Surface-Functionalizing Metal, Metal Oxide and Semiconductor Nanocrystals with a Multi-coordinating Polymer Platform Wentao Wang, Xin Ji, Anshika Kapur and Hedi Mattoussi MRS Advances / FirstView Article / May 2016, pp 1 - 7 DOI: 10.1557/adv.2016.375, Published online: 20 May 2016
Link to this article: http://journals.cambridge.org/abstract_S2059852116003753 How to cite this article: Wentao Wang, Xin Ji, Anshika Kapur and Hedi Mattoussi Surface-Functionalizing Metal, Metal Oxide and Semiconductor Nanocrystals with a Multi-coordinating Polymer Platform. MRS Advances, Available on CJO 2016 doi:10.1557/adv.2016.375 Request Permissions : Click here
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MRS Advances © 2016 Materials Research Society DOI: 10.1557/adv.2016.375
Surface-Functionalizing Metal, Metal Oxide and Semiconductor Nanocrystals with a Multi-coordinating Polymer Platform Wentao Wang, Xin Ji, Anshika Kapur, and Hedi Mattoussi Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 ABSTRACT We introduce a new set of multifunctional metal-coordinating polymers as ligands for the surface functionalization of three different inorganic nanocrystals: luminescent quantum dots (QDs), magnetic iron oxide nanocrystals and metal gold nanoparticles. The ligand design relies on the introduction of a large but controllable number of anchoring groups, hydrophilic moieties and reactive functionalities all in the same polymer chain, via a one-step nucleophilic addition reaction. Nanocrystals capped with these polymer ligands exhibit long-term stability over a broad range of biological conditions. Furthermore, when zwitterion groups are introduced as hydrophilic blocks, this yields a compact ligand coating that allows conjugation of biomolecules to the nanocrystals via metal-histidine self-assembly. The resulting hydrophilic nanocrystals have been used to develop a few specific sensing platforms targeting soluble iron ions and cysteine. INTRODUCTION Nanomaterials made of semiconductors, metals and metal oxides possess unique optical and physical properties which can be tuned via size and/or composition.1-3 For instance, semiconductor nanocrystals such as those made of ZnS-overcoated CdSe QDs exhibit narrow tunable emission throughout the visible spectrum, combined with high quantum yield and extended photo-stability.4-7 An effective integration of these inorganic nanomaterials into biological systems has the potential to provide novel hybrid platforms that can advance our understandings of several challenging problems in biology.8, 9 This, however, requires access to hydrophilic nanoparticles that are colloidally stable and present surface-reactive groups.10, 11 Cap exchange with bifunctional coordinating ligands has been used by several groups to promote the dispersion of various inorganic nanocrystals in buffer media. This s
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